Manganese Dynamics in Mouse Brain After Systemic MnCl₂ Administration for Activation-Induced Manganese-Enhanced MRI.

ABSTRACT: Activation-induced manganese-enhanced MRI (AIM-MRI) is an attractive tool for non-invasively mapping whole brain activities. Manganese ions (Mn²⁺) enter and accumulate in active neurons via calcium channels. Mn²⁺ shortens the longitudinal relaxation time (T1) of H⁺, and the longitudinal relaxation rate R1 (1/T1) is proportional to Mn²⁺ concentration. Thus, AIM-MRI can map neural activities throughout the brain by assessing the R1 map. However, AIM-MRI is still not widely used, partially due to insufficient information regarding Mn²⁺ dynamics in the brain. To resolve this issue, we conducted a longitudinal study looking at manganese dynamics after systemic administration of MnCl₂ by AIM-MRI with quantitative analysis. In the

SUBMITTER: Tanihira H 

PROVIDER: S-EPMC8722453 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature