Lgr5? amacrine cells possess regenerative potential in the retina of adult mice.
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ABSTRACT:
SUBMITTER: Chen M
PROVIDER: S-EPMC4531077 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Lgr5⁺ amacrine cells possess regenerative potential in the retina of adult mice.
Chen Mengfei M Tian Shenghe S Glasgow Nathan G NG Gibson Gregory G Yang Xiaoling X Shiber Christen E CE Funderburgh James J Watkins Simon S Johnson Jon W JW Schuman Joel S JS Liu Hongjun H
Aging cell 20150520 4
Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult mice. Lgr5(+) cells are generated at late stages of retinal development and exhibit properties of differentiated amacrine interneurons (amacrine cells). Nevertheless, Lgr5(+) amacrine cells contribute to regeneration of new retinal cells in the adult stage. Th ...[more]
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