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Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts.

ABSTRACT: The regenerative potential of cardiosphere-derived cells (CDCs) for ischaemic heart disease has been demonstrated in mice, rats, pigs and a recently completed clinical trial. The regenerative potential of CDCs from dog hearts has yet to be tested. Here, we show that canine CDCs can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings. Canine CDCs can differentiate into cardiomyocytes, smooth muscle cells and endothelial cells in vitro. In addition, conditioned media from canine CDCs promote angiogenesis but inhibit cardiomyocyte death. In a doxorubicin-induced mouse model of dilated cardiomyopathy (DCM), intravenous infusion of canine CDCs improves cardiac function and decreases cardiac fibrosis. Histology revealed that injected canine CDCs engraft in the mouse heart and increase capillary density. Out study demonstrates the regenerative potential of canine CDCs in a mouse model of DCM.

SUBMITTER: Hensley MT 

PROVIDER: S-EPMC4549031 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts.

Hensley Michael Taylor MT   de Andrade James J   Keene Bruce B   Meurs Kathryn K   Tang Junnan J   Wang Zegen Z   Caranasos Thomas G TG   Piedrahita Jorge J   Li Tao-Sheng TS   Cheng Ke K  

Journal of cellular and molecular medicine 20150409 8

The regenerative potential of cardiosphere-derived cells (CDCs) for ischaemic heart disease has been demonstrated in mice, rats, pigs and a recently completed clinical trial. The regenerative potential of CDCs from dog hearts has yet to be tested. Here, we show that canine CDCs can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings. Canine CDCs can differentiate into cardiomyocytes, smooth muscl  ...[more]

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