Metabolic engineering of Escherichia coli for the production of 1,3-diaminopropane, a three carbon diamine.
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ABSTRACT:
SUBMITTER: Chae TU
PROVIDER: S-EPMC4531320 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Metabolic engineering of Escherichia coli for the production of 1,3-diaminopropane, a three carbon diamine.
Chae Tong Un TU Kim Won Jun WJ Choi Sol S Park Si Jae SJ Lee Sang Yup SY
Scientific reports 20150811
Bio-based production of chemicals from renewable resources is becoming increasingly important for sustainable chemical industry. In this study, Escherichia coli was metabolically engineered to produce 1,3-diaminopropane (1,3-DAP), a monomer for engineering plastics. Comparing heterologous C4 and C5 pathways for 1,3-DAP production by genome-scale in silico flux analysis revealed that the C4 pathway employing Acinetobacter baumannii dat and ddc genes, encoding 2-ketoglutarate 4-aminotransferase an ...[more]
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