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Neurobiological indicators of disinhibition in posttraumatic stress disorder.

ABSTRACT: Deficits in impulse control are increasingly recognized in association with posttraumatic stress disorder (PTSD). To our further understanding of the neurobiology of PTSD-related disinhibition, we examined alterations in brain morphology and network connectivity associated with response inhibition failures and PTSD severity. The sample consisted of 189 trauma-exposed Operation Enduring Freedom/Operation Iraqi Freedom veterans (89% male, ages 19-62) presenting with a range of current PTSD severity. Disinhibition was measured using commission errors on a Go/No-Go (GNG) task with emotional stimuli, and PTSD was assessed using a measure of current symptom severity. Whole-brain vertex-wise analyses of cortical thickness revealed two clusters associated with PTSD-related disinhibition (Monte Carlo cluster corrected P?

SUBMITTER: Sadeh N

PROVIDER: S-EPMC4532949 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Neurobiological indicators of disinhibition in posttraumatic stress disorder.

Sadeh Naomi N Spielberg Jeffrey M JM Miller Mark W MW Milberg William P WP Salat David H DH Amick Melissa M MM Fortier Catherine B CB McGlinchey Regina E RE

Human brain mapping 20150509 8

Deficits in impulse control are increasingly recognized in association with posttraumatic stress disorder (PTSD). To our further understanding of the neurobiology of PTSD-related disinhibition, we examined alterations in brain morphology and network connectivity associated with response inhibition failures and PTSD severity. The sample consisted of 189 trauma-exposed Operation Enduring Freedom/Operation Iraqi Freedom veterans (89% male, ages 19-62) presenting with a range of current PTSD severit ...[more]

PMID: 25959594

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