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Posttraumatic Stress Disorder: an integrated overview and neurobiological rationale for pharmacology.


ABSTRACT: Thirty years of research on the biology of posttraumatic stress disorder now provides a foundation for hypotheses related to the mechanisms underlying the pharmacotherapy of this disorder. Only two medications, sertraline and paroxetine, are approved by the U.S. Food and Drug Administration for the treatment of PTSD. While these medications are somewhat effective, other treatment mechanisms must be explored to address the unmet need for effective treatment. This article provides a concise summary of advances in our understanding of the neurobiology of PTSD that suggest novel approaches to pharmacotherapy.

SUBMITTER: Kelmendi B 

PROVIDER: S-EPMC6688474 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Posttraumatic Stress Disorder: an integrated overview and neurobiological rationale for pharmacology.

Kelmendi Benjamin B   Adams Thomas G TG   Southwick Steven S   Abdallah Chadi G CG   Krystal John H JH  

Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association 20170718 3


Thirty years of research on the biology of posttraumatic stress disorder now provides a foundation for hypotheses related to the mechanisms underlying the pharmacotherapy of this disorder. Only two medications, sertraline and paroxetine, are approved by the U.S. Food and Drug Administration for the treatment of PTSD. While these medications are somewhat effective, other treatment mechanisms must be explored to address the unmet need for effective treatment. This article provides a concise summar  ...[more]

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