Ontology highlight
ABSTRACT:
SUBMITTER: Mahajan K
PROVIDER: S-EPMC4533924 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Mahajan Kiran K Fang Bin B Koomen John M JM Mahajan Nupam P NP
Nature structural & molecular biology 20120812 9
Histone gene transcription is actively downregulated after completion of DNA synthesis to avoid overproduction. However, the precise mechanistic details of the cessation of histone mRNA synthesis are not clear. We found that histone H2B phosphorylation at Tyr37 occurs upstream of histone cluster 1, Hist1, during the late S phase. We identified WEE1 as the kinase that phosphorylates H2B at Tyr37. Loss of expression or inhibition of WEE1 kinase abrogated H2B Tyr37 phosphorylation with a concomitan ...[more]