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The impact of vitamin D3 supplementation on muscle function among HIV-infected children and young adults: a randomized controlled trial.


ABSTRACT: We tested the hypothesis that daily vitD3 supplementation increases neuromuscular motor skills, jump power, jump energy, muscular force, and muscular strength.This was a secondary analysis of a randomized controlled trial of 12-months of oral 7,000 IU/day vitD3 supplementation or placebo among 56 persons living with HIV aged 9-25 years. Neuromuscular motor skills were quantified using the Bruininks-Oseretsky Test of Motor Proficiency. Power was quantified using peak jump power, and energy was quantified using peak jump height. Muscular force was quantified using isometric ankle plantar- and dorsiflexion, isokinetic knee flexion and extension. Muscular strength was quantified using isometric handgrip strength.After 12-months, serum 25-hydroxyvitamin D [25(OH)D] was higher with supplementation versus placebo (?=12.1 ng/mL; P<0.001). In intention-to-treat analyses, supplementation improved neuromuscular motor skills versus placebo (?=1.14; P=0.041). We observed no effect of supplementation on jump power, jump energy, muscular force, or muscular strength outcomes versus placebo.Among HIV-infected children and young adults supplementation with daily high-dose vitD3 increased concentration of serum 25(OH)D and improved neuromuscular motor skills versus placebo.

SUBMITTER: Brown JC 

PROVIDER: S-EPMC4533987 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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The impact of vitamin D3 supplementation on muscle function among HIV-infected children and young adults: a randomized controlled trial.

Brown J C JC   Schall J I JI   Rutstein R M RM   Leonard M B MB   Zemel B S BS   Stallings V A VA  

Journal of musculoskeletal & neuronal interactions 20150601 2


<h4>Objectives</h4>We tested the hypothesis that daily vitD3 supplementation increases neuromuscular motor skills, jump power, jump energy, muscular force, and muscular strength.<h4>Methods</h4>This was a secondary analysis of a randomized controlled trial of 12-months of oral 7,000 IU/day vitD3 supplementation or placebo among 56 persons living with HIV aged 9-25 years. Neuromuscular motor skills were quantified using the Bruininks-Oseretsky Test of Motor Proficiency. Power was quantified using  ...[more]

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