Ontology highlight
ABSTRACT:
SUBMITTER: Vantangoli MM
PROVIDER: S-EPMC4534042 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Vantangoli Marguerite M MM Madnick Samantha J SJ Huse Susan M SM Weston Paula P Boekelheide Kim K
PloS one 20150812 8
Three-dimensional (3D) cultures are increasing in use because of their ability to represent in vivo human physiology when compared to monolayer two-dimensional (2D) cultures. When grown in 3D using scaffold-free agarose hydrogels, MCF-7 human breast cancer cells self-organize to form directionally-oriented microtissues that contain a luminal space, reminiscent of the in vivo structure of the mammary gland. When compared to MCF-7 cells cultured in 2D monolayer culture, MCF-7 microtissues exhibit ...[more]