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Mother's pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood.


ABSTRACT: Maternal adiposity is associated with poor offspring cardiometabolic health. We aimed to evaluate the relationship of maternal pre-pregnancy body mass index (BMI) on the BMI, body composition and cardiometabolic characteristics of the offspring.Forty offspring of overweight/obese mothers (O-OW) and 28 offspring of normal weight mothers (O-NW) underwent evaluation of body composition, abdominal fat distribution, blood pressure measurement, fasting lipids and an oral glucose tolerance test. The anthropometric and cardiometabolic characteristics of O-OW were compared with those of O-NW, and the relationship to maternal BMI was evaluated.Subjects (mean age: 12.6?±?0.4, female: 52.9%) had similar gestational age, birth weight, age, gender, and Tanner stage. However, O-OW had a significantly higher BMI (24.4?±?1.2 vs. 19.7?±?0.8?kg/m(2) , p?=?0.001), % body fat (31.7?±?1.6 vs. 24.6?±?1.1%, p?

SUBMITTER: Tan HC 

PROVIDER: S-EPMC4534350 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Mother's pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood.

Tan Hong Chang HC   Roberts James J   Catov Janet J   Krishnamurthy Ramkumar R   Shypailo Roman R   Bacha Fida F  

Pediatric diabetes 20150320 6


<h4>Objective</h4>Maternal adiposity is associated with poor offspring cardiometabolic health. We aimed to evaluate the relationship of maternal pre-pregnancy body mass index (BMI) on the BMI, body composition and cardiometabolic characteristics of the offspring.<h4>Methods</h4>Forty offspring of overweight/obese mothers (O-OW) and 28 offspring of normal weight mothers (O-NW) underwent evaluation of body composition, abdominal fat distribution, blood pressure measurement, fasting lipids and an o  ...[more]

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