Ontology highlight
ABSTRACT:
SUBMITTER: Rzechorzek NM
PROVIDER: S-EPMC4534756 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Rzechorzek Nina Marie NM Connick Peter P Patani Rickie R Selvaraj Bhuvaneish Thangaraj BT Chandran Siddharthan S
EBioMedicine 20150411 6
Hypothermia is potently neuroprotective but poor mechanistic understanding has restricted its clinical use. Rodent studies indicate that hypothermia can elicit preconditioning, wherein a subtoxic cellular stress confers resistance to an otherwise lethal injury. The molecular basis of this preconditioning remains obscure. Here we explore molecular effects of cooling using functional cortical neurons differentiated from human pluripotent stem cells (hCNs). Mild-to-moderate hypothermia (28-32 °C) i ...[more]