Stimulation of the Drosophila immune system alters genome-wide nucleosome occupancy.
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ABSTRACT:
SUBMITTER: Ren Y
PROVIDER: S-EPMC4535615 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Stimulation of the Drosophila immune system alters genome-wide nucleosome occupancy.
Ren Yingxue Y Vera Daniel L DL Hughes Kimberly A KA Dennis Jonathan H JH
Genomics data 20150109
In eukaryotes, nucleosomes participate in all DNA-templated events by regulating access to the underlying DNA sequence. However, nucleosome dynamics during a genome response have not been well characterized [1,2]. We stimulated Drosophila S2 cells with heat-killed Gram-negative bacteria Salmonella typhimurium, and mapped genome-wide nucleosome occupancy at high temporal resolution by MNase-seq using Illumina HiSeq 2500. We show widespread nucleosome occupancy change in S2 cells during the immune ...[more]
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