Ontology highlight
ABSTRACT:
SUBMITTER: Statham AL
PROVIDER: S-EPMC4535833 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Statham Aaron L AL Taberlay Phillippa C PC Kelly Theresa K TK Jones Peter A PA Clark Susan J SJ
Genomics data 20141208
DNA methylation and nucleosome positioning are two key mechanisms that contribute to the epigenetic control of gene expression. During carcinogenesis, the expression of many genes is altered alongside extensive changes in the epigenome, with repressed genes often being associated with local DNA hypermethylation and gain of nucleosomes at their promoters. However the spectrum of alterations that occur at distal regulatory regions has not been extensively studied. To address this we used Nucleosom ...[more]