Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity.
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ABSTRACT:
SUBMITTER: Lin RC
PROVIDER: S-EPMC4536069 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
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Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity.
Lin Ruby C Y RC Ng Sheau-Fang SF Morris Margaret J MJ
Genomics data 20141016
Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963-966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830-1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the ...[more]
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