Metazoan tRNA introns generate stable circular RNAs in vivo.
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ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC4536317 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Metazoan tRNA introns generate stable circular RNAs in vivo.
Lu Zhipeng Z Filonov Grigory S GS Noto John J JJ Schmidt Casey A CA Hatkevich Talia L TL Wen Ying Y Jaffrey Samie R SR Matera A Gregory AG
RNA (New York, N.Y.) 20150720 9
We report the discovery of a class of abundant circular noncoding RNAs that are produced during metazoan tRNA splicing. These transcripts, termed tRNA intronic circular (tric)RNAs, are conserved features of animal transcriptomes. Biogenesis of tricRNAs requires anciently conserved tRNA sequence motifs and processing enzymes, and their expression is regulated in an age-dependent and tissue-specific manner. Furthermore, we exploited this biogenesis pathway to develop an in vivo expression system f ...[more]
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