Ontology highlight
ABSTRACT:
SUBMITTER: Silveira AB
PROVIDER: S-EPMC4537002 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Silveira André Bortolini AB Laranjeira Angelo Brunelli Albertoni AB Rodrigues Gisele Olinto Libanio GO Leal Paulo César PC Cardoso Bruno António BA Barata João Taborda JT Yunes Rosendo Augusto RA Zanchin Nilson Ivo Tonin NI Brandalise Sílvia Regina SR Yunes José Andrés JA
Oncotarget 20150501 15
The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K pathway has been suggested as one mechanism of glucocorticoid resistance in T-ALL, and patients harboring mutations in the PI3K negative regulator PTEN may be at increased risk of induction failure and relapse. By gene expression microarray analysis of T-ALL cells treated with the PI3K inhibitor AS605240, we identified Myc as a prominent downstream target of the PI3K ...[more]