Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Canaveras JC
PROVIDER: S-EPMC7647950 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
García-Cañaveras Juan C JC Lancho Olga O Ducker Gregory S GS Ghergurovich Jonathan M JM Xu Xincheng X da Silva-Diz Victoria V Minuzzo Sonia S Indraccolo Stefano S Kim Hahn H Herranz Daniel D Rabinowitz Joshua D JD
Leukemia 20200507 2
Folate metabolism enables cell growth by providing one-carbon (1C) units for nucleotide biosynthesis. The 1C units are carried by tetrahydrofolate, whose production by the enzyme dihydrofolate reductase is targeted by the important anticancer drug methotrexate. 1C units come largely from serine catabolism by the enzyme serine hydroxymethyltransferase (SHMT), whose mitochondrial isoform is strongly upregulated in cancer. Here we report the SHMT inhibitor SHIN2 and demonstrate its in vivo target e ...[more]