Ontology highlight
ABSTRACT:
SUBMITTER: Kolahgar G
PROVIDER: S-EPMC4537514 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Kolahgar Golnar G Suijkerbuijk Saskia J E SJ Kucinski Iwo I Poirier Enzo Z EZ Mansour Sarah S Simons Benjamin D BD Piddini Eugenia E
Developmental cell 20150723 3
Throughout their lifetime, cells may suffer insults that reduce their fitness and disrupt their function, and it is unclear how these potentially harmful cells are managed in adult tissues. We address this question using the adult Drosophila posterior midgut as a model of homeostatic tissue and ribosomal Minute mutations to reduce fitness in groups of cells. We take a quantitative approach combining lineage tracing and biophysical modeling and address how cell competition affects stem cell and t ...[more]