The association study on renalase polymorphism and hypertension: a meta-analysis.

ABSTRACT: Hypertension is considered a multi-factorial disease since its development is affected by both genetic and environmental factors. Intensive efforts have been focused on identifying gene(s) related to hypertension. Renalase is a recently discovered protein that expressed in kidney, heart, liver, and brain that metabolizes catecholamines, regulation of blood pressure in humans and animals. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. But the reported results are not always consistent. In this meta-analysis, we examined the association between (Glu37Asp) polymorphism (rs2296545) in renalase gene and risk of hypertension. Through a systematic literature search for publications between 2007 and 2014, w

SUBMITTER: Shi WB 

PROVIDER: S-EPMC4537962 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature