Ontology highlight
ABSTRACT:
SUBMITTER: Pak OS
PROVIDER: S-EPMC4538622 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Pak On Shun OS Young Y-N YN Marple Gary R GR Veerapaneni Shravan S Stone Howard A HA
Proceedings of the National Academy of Sciences of the United States of America 20150727 32
A multiscale continuum model is constructed for a mechanosensitive (MS) channel gated by tension in a lipid bilayer membrane under stresses due to fluid flows. We illustrate that for typical physiological conditions vesicle hydrodynamics driven by a fluid flow may render the membrane tension sufficiently large to gate a MS channel open. In particular, we focus on the dynamic opening/closing of a MS channel in a vesicle membrane under a planar shear flow and a pressure-driven flow across a constr ...[more]