Ontology highlight
ABSTRACT:
SUBMITTER: Reddy B
PROVIDER: S-EPMC7299334 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Reddy Bharat B Bavi Navid N Lu Allen A Park Yeonwoo Y Perozo Eduardo E
eLife 20191227
Prokaryotic mechanosensitive (MS) channels open by sensing the physical state of the membrane. As such, lipid-protein interactions represent the defining molecular process underlying mechanotransduction. Here, we describe cryo-electron microscopy (cryo-EM) structures of the <i>E. coli</i> small-conductance mechanosensitive channel (MscS) in nanodiscs (ND). They reveal a novel membrane-anchoring fold that plays a significant role in channel activation and establish a new location for the lipid bi ...[more]