Ontology highlight
ABSTRACT:
SUBMITTER: Calligaris D
PROVIDER: S-EPMC4538649 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Calligaris David D Feldman Daniel R DR Norton Isaiah I Olubiyi Olutayo O Changelian Armen N AN Machaidze Revaz R Vestal Matthew L ML Laws Edward R ER Dunn Ian F IF Santagata Sandro S Agar Nathalie Y R NY
Proceedings of the National Academy of Sciences of the United States of America 20150727 32
We present a proof of concept study designed to support the clinical development of mass spectrometry imaging (MSI) for the detection of pituitary tumors during surgery. We analyzed by matrix-assisted laser desorption/ionization (MALDI) MSI six nonpathological (NP) human pituitary glands and 45 hormone secreting and nonsecreting (NS) human pituitary adenomas. We show that the distribution of pituitary hormones such as prolactin (PRL), growth hormone (GH), adrenocorticotropic hormone (ACTH), and ...[more]