Ontology highlight
ABSTRACT:
SUBMITTER: Mohan N
PROVIDER: S-EPMC4538844 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Mohan Nimmy N Sudheesh A P AP Francis Nimmy N Anderson Richard R Laishram Rakesh S RS
Nucleic acids research 20150702 14
Star-PAP is a nuclear non-canonical poly(A) polymerase (PAP) that shows specificity toward mRNA targets. Star-PAP activity is stimulated by lipid messenger phosphatidyl inositol 4,5 bisphoshate (PI4,5P2) and is regulated by the associated Type I phosphatidylinositol-4-phosphate 5-kinase that synthesizes PI4,5P2 as well as protein kinases. These associated kinases act as coactivators of Star-PAP that regulates its activity and specificity toward mRNAs, yet the mechanism of control of these intera ...[more]