Ontology highlight
ABSTRACT:
SUBMITTER: Kandala DT
PROVIDER: S-EPMC4737136 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kandala Divya T DT Mohan Nimmy N A Vivekanand V A P Sudheesh S G Reshmi R Laishram Rakesh S RS
Nucleic acids research 20151022 2
Almost all eukaryotic mRNAs have a poly (A) tail at the 3'-end. Canonical PAPs (PAPα/γ) polyadenylate nuclear pre-mRNAs. The recent identification of the non-canonical Star-PAP revealed specificity of nuclear PAPs for pre-mRNAs, yet the mechanism how Star-PAP selects mRNA targets is still elusive. Moreover, how Star-PAP target mRNAs having canonical AAUAAA signal are not regulated by PAPα is unclear. We investigate specificity mechanisms of Star-PAP that selects pre-mRNA targets for polyadenylat ...[more]