Ontology highlight
ABSTRACT:
SUBMITTER: Subbian S
PROVIDER: S-EPMC4539171 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Subbian Selvakumar S Pandey Ruchi R Soteropoulos Patricia P Rodriguez G Marcela GM
Journal of immunology research 20150803
Mycobacterium tuberculosis the causative agent of tuberculosis affects millions of people worldwide. New tools for treatment and prevention of tuberculosis are urgently needed. We previously showed that a ferritin (bfrB) mutant of M. tuberculosis has altered iron homeostasis and increased sensitivity to antibiotics and to microbicidal effectors produced by activated macrophages. Most importantly, M. tuberculosis lacking BfrB is strongly attenuated in mice, especially, during the chronic phase of ...[more]