Ontology highlight
ABSTRACT:
SUBMITTER: Shi J
PROVIDER: S-EPMC4539557 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Shi Jianli J Zhao Ying Y Galati Domenico D Winey Mark M Klymkowsky Michael W MW
Developmental biology 20140916 2
Wnt signaling and ciliogenesis are core features of embryonic development in a range of metazoans. Chibby (Cby), a basal-body associated protein, regulates β-catenin-mediated Wnt signaling in the mouse but not Drosophila. Here we present an analysis of Cby's embryonic expression and morphant phenotypes in Xenopus laevis. Cby RNA is supplied maternally, negatively regulated by Snail2 but not Twist1, preferentially expressed in the neuroectoderm, and regulates β-catenin-mediated gene expression. R ...[more]