Ontology highlight
ABSTRACT:
SUBMITTER: Kunsmann L
PROVIDER: S-EPMC4539607 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20150818
The highly virulent Escherichia coli O104:H4 that caused the large 2011 outbreak of diarrhoea and haemolytic uraemic syndrome secretes blended virulence factors of enterohaemorrhagic and enteroaggregative E. coli, but their secretion pathways are unknown. We demonstrate that the outbreak strain releases a cocktail of virulence factors via outer membrane vesicles (OMVs) shed during growth. The OMVs contain Shiga toxin (Stx) 2a, the major virulence factor of the strain, Shigella enterotoxin 1, H4 ...[more]