Ontology highlight
ABSTRACT:
SUBMITTER: Perkins MR
PROVIDER: S-EPMC4539895 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Perkins Molly R MR Bartha Istvan I Timmer J Katherina JK Liebner Julia C JC Wolinsky David D Günthard Huldrych F HF Hauser Christoph C Bernasconi Enos E Hoffmann Matthias M Calmy Alexandra A Battegay Manuel M Telenti Amalio A Douek Daniel C DC Fellay Jacques J
The Journal of infectious diseases 20150220 4
Systemic immune activation, a major determinant of human immunodeficiency virus (HIV) disease progression, is the result of a complex interplay between viral replication, dysregulation of the immune system, and microbial translocation due to gut mucosal damage. Although human genetic variants influencing HIV load have been identified, it is unknown how much the host genetic background contributes to interindividual differences in other determinants of HIV pathogenesis such as gut damage and micr ...[more]