Ontology highlight
ABSTRACT:
SUBMITTER: Thomas DG
PROVIDER: S-EPMC4539979 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Thomas Dustin G DG Yenepalli Aishwarya A Denais Celine Marie CM Rape Andrew A Beach Jordan R JR Wang Yu-Li YL Schiemann William P WP Baskaran Harihara H Lammerding Jan J Egelhoff Thomas T TT
The Journal of cell biology 20150810 4
Non-muscle myosin II (NMII) is reported to play multiple roles during cell migration and invasion. However, the exact biophysical roles of different NMII isoforms during these processes remain poorly understood. We analyzed the contributions of NMIIA and NMIIB in three-dimensional (3D) migration and in generating the forces required for efficient invasion by mammary gland carcinoma cells. Using traction force microscopy and microfluidic invasion devices, we demonstrated that NMIIA is critical fo ...[more]