Ontology highlight
ABSTRACT:
SUBMITTER: Pfalzer AC
PROVIDER: S-EPMC4540493 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Pfalzer Anna C AC Nesbeth Paula-Dene C PD Parnell Laurence D LD Iyer Lakshmanan K LK Liu Zhenhua Z Kane Anne V AV Chen C-Y Oliver CY Tai Albert K AK Bowman Thomas A TA Obin Martin S MS Mason Joel B JB Greenberg Andrew S AS Choi Sang-Woon SW Selhub Jacob J Paul Ligi L Crott Jimmy W JW
PloS one 20150818 8
Obesity is a risk factor for colorectal cancer (CRC), and alterations in the colonic microbiome and metabolome may be mechanistically involved in this relationship. The relative contribution of diet and obesity per se are unclear. We compared the effect of diet- and genetically-induced obesity on the intestinal microbiome and metabolome in a mouse model of CRC. Apc1638N mice were made obese by either high fat (HF) feeding or the presence of the Leprdb/db (DbDb) mutation. Intestinal tumors were q ...[more]