Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity.
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ABSTRACT:
SUBMITTER: Hild B
PROVIDER: S-EPMC9969744 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity.
Hild Benedikt B Dreier Matthew S MS Oh Ji Hoon JH McCulloch John A JA Badger Jonathan H JH Guo Juen J Thefaine Claire E CE Umarova Regina R Hall Kevin D KD Gavrilova Oksana O Rosshart Stephan P SP Trinchieri Giorgio G Rehermann Barbara B
Nature metabolism 20210820 8
Obesity and its consequences are among the greatest challenges in healthcare. The gut microbiome is recognized as a key factor in the pathogenesis of obesity. Using a mouse model, we show here that a wild-derived microbiome protects against excessive weight gain, severe fatty liver disease and metabolic syndrome during a 10-week course of high-fat diet. This phenotype is transferable only during the first weeks of life. In adult mice, neither transfer nor severe disturbance of the wild-type micr ...[more]
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