Ontology highlight
ABSTRACT:
SUBMITTER: Pietras EM
PROVIDER: S-EPMC4542150 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Pietras Eric M EM Reynaud Damien D Kang Yoon-A YA Carlin Daniel D Calero-Nieto Fernando J FJ Leavitt Andrew D AD Stuart Joshua M JM Göttgens Berthold B Passegué Emmanuelle E
Cell stem cell 20150618 1
Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production. We find that all MPPs are produced in parallel by hematopoietic stem cells (HSCs), but with different kinetics and at variable levels depending on hematopoietic demand ...[more]