Ontology highlight
ABSTRACT:
SUBMITTER: Bottardi S
PROVIDER: S-EPMC1538551 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Bottardi Stefania S Ross Julie J Pierre-Charles Natacha N Blank Volker V Milot Eric E
The EMBO journal 20060713 15
During development, the regulated expression of tissue-specific genes can be preceded by their potentiation, that is, by chromatin activation in progenitor cells. For example, the human beta-like globin genes are potentiated in a gene- and developmental-specific manner in hematopoietic progenitors. Developmental regulation of human beta-gene expression in erythroid cells is mostly determined by transcriptional activators; however, it is not clear how gene-specific potentiation is set in hematopo ...[more]