Ontology highlight
ABSTRACT:
SUBMITTER: Pederick VG
PROVIDER: S-EPMC4542158 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Pederick Victoria G VG Eijkelkamp Bart A BA Begg Stephanie L SL Ween Miranda P MP McAllister Lauren J LJ Paton James C JC McDevitt Christopher A CA
Scientific reports 20150820
Pseudomonas aeruginosa is a ubiquitous environmental bacterium and a clinically significant opportunistic human pathogen. Central to the ability of P. aeruginosa to colonise both environmental and host niches is the acquisition of zinc. Here we show that P. aeruginosa PAO1 acquires zinc via an ATP-binding cassette (ABC) permease in which ZnuA is the high affinity, zinc-specific binding protein. Zinc uptake in Gram-negative organisms predominantly occurs via an ABC permease, and consistent with t ...[more]