Ontology highlight
ABSTRACT:
SUBMITTER: Vietri Rudan M
PROVIDER: S-EPMC4542312 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Vietri Rudan Matteo M Barrington Christopher C Henderson Stephen S Ernst Christina C Odom Duncan T DT Tanay Amos A Hadjur Suzana S
Cell reports 20150226 8
Topological domains are key architectural building blocks of chromosomes, but their functional importance and evolutionary dynamics are not well defined. We performed comparative high-throughput chromosome conformation capture (Hi-C) in four mammals and characterized the conservation and divergence of chromosomal contact insulation and the resulting domain architectures within distantly related genomes. We show that the modular organization of chromosomes is robustly conserved in syntenic region ...[more]