Ontology highlight
ABSTRACT:
SUBMITTER: Yaffe E
PROVIDER: S-EPMC2895651 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Yaffe Eitan E Farkash-Amar Shlomit S Polten Andreas A Yakhini Zohar Z Tanay Amos A Simon Itamar I
PLoS genetics 20100701 7
Recent evidence suggests that the timing of DNA replication is coordinated across megabase-scale domains in metazoan genomes, yet the importance of this aspect of genome organization is unclear. Here we show that replication timing is remarkably conserved between human and mouse, uncovering large regions that may have been governed by similar replication dynamics since these species have diverged. This conservation is both tissue-specific and independent of the genomic G+C content conservation. ...[more]