Ontology highlight
ABSTRACT:
SUBMITTER: Tomazou EM
PROVIDER: S-EPMC4542316 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Tomazou Eleni M EM Sheffield Nathan C NC Schmidl Christian C Schuster Michael M Schönegger Andreas A Datlinger Paul P Kubicek Stefan S Bock Christoph C Kovar Heinrich H
Cell reports 20150219 7
Transcription factor fusion proteins can transform cells by inducing global changes of the transcriptome, often creating a state of oncogene addiction. Here, we investigate the role of epigenetic mechanisms in this process, focusing on Ewing sarcoma cells that are dependent on the EWS-FLI1 fusion protein. We established reference epigenome maps comprising DNA methylation, seven histone marks, open chromatin states, and RNA levels, and we analyzed the epigenome dynamics upon downregulation of the ...[more]