Ontology highlight
ABSTRACT:
SUBMITTER: Pennock R
PROVIDER: S-EPMC4542335 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Pennock Rebecca R Bray Elen E Pryor Paul P James Sally S McKeegan Paul P Sturmey Roger R Genever Paul P
Scientific reports 20150820
Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacement tissues develop. Human somatic cells cannot regenerate in this way and differentiation is considered irreversible under normal developmental conditions. Here, we sought to establish in vitro conditions to mimic blastema formation by generating di ...[more]