Progress toward overcoming hypoxia-induced resistance to solid tumor therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Karakashev SV
PROVIDER: S-EPMC4542411 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Progress toward overcoming hypoxia-induced resistance to solid tumor therapy.
Karakashev Sergey V SV Reginato Mauricio J MJ
Cancer management and research 20150812
Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Her ...[more]
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