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Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.

ABSTRACT: Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.

SUBMITTER: van de Sandt CE

PROVIDER: S-EPMC4542594 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.

van de Sandt Carolien E CE Hillaire Marine L B ML Geelhoed-Mieras Martina M MM Osterhaus Albert D M E AD Fouchier Ron A M RA Rimmelzwaan Guus F GF

The Journal of infectious diseases 20150112 1

Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular ...[more]

PMID: 25583167

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