Ontology highlight
ABSTRACT:
SUBMITTER: Wu CY
PROVIDER: S-EPMC7722854 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Wu Chung-Yi CY Chuang Hong-Yang HY Wong Chi-Huey CH
Communications biology 20201208 1
Influenza A virus (IAV)-specific CD8<sup>+</sup> T-cell response was shown to provide protection against pandemic and seasonal influenza infections. However, the response was often relatively weak and the mechanism was unclear. Here, we show that the composition of IAV released from infected cells is regulated by the neuraminidase (NA) activity and the cells infected by NA-defective virus cause intracellular viral protein accumulation and cell death. In addition, after uptake of NA-defective vir ...[more]