Ontology highlight
ABSTRACT:
SUBMITTER: Ishigaki K
PROVIDER: S-EPMC4542667 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Ishigaki Kazuyoshi K Shoda Hirofumi H Kochi Yuta Y Yasui Tetsuro T Kadono Yuho Y Tanaka Sakae S Fujio Keishi K Yamamoto Kazuhiko K
Scientific reports 20150806
Rheumatoid arthritis (RA) is an autoimmune destructive arthritis associated with CD4(+) T cell-mediated immunity. Although expanded CD4(+) T cell clones (ECs) has already been confirmed, the detailed characteristics of ECs have not been elucidated in RA. Using combination of a single-cell analysis and next-generation sequencing (NGS) in TCR repertoire analysis, we here revealed the detailed nature of ECs by examining peripheral blood (PB) from 5 RA patients and synovium from 1 RA patient. When w ...[more]