Ontology highlight
ABSTRACT:
SUBMITTER: Koizumi T
PROVIDER: S-EPMC4542694 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Koizumi Taichi T Terada Tohru T Nakajima Ken-ichiro K Kojima Masaki M Koshiba Seizo S Matsumura Yoshitaka Y Kaneda Kohei K Asakura Tomiko T Shimizu-Ibuka Akiko A Abe Keiko K Misaka Takumi T
Scientific reports 20150811
Neoculin (NCL) is a heterodimeric protein isolated from the edible fruit of Curculigo latifolia. It exerts a taste-modifying activity by converting sourness to sweetness. We previously demonstrated that NCL changes its action on the human sweet receptor hT1R2-hT1R3 from antagonism to agonism as the pH changes from neutral to acidic values, and that the histidine residues of NCL molecule play critical roles in this pH-dependent functional change. Here, we comprehensively screened key amino acid r ...[more]