Ontology highlight
ABSTRACT:
SUBMITTER: Goldstein BA
PROVIDER: S-EPMC4543537 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Goldstein Benjamin A BA Yang Lingyao L Salfati Elias E Assimes Themistoclies L TL
Genetic epidemiology 20150722 6
Genetic risk scores are an increasingly popular tool for summarizing the cumulative risk of a set of Single Nucleotide Polymorphisms (SNPs) with disease. Typically only the set of the SNPs that have reached genome-wide significance compose these scores. However recent work suggests that including additional SNPs may aid risk assessment. In this paper, we used the Atherosclerosis Risk in Communities (ARIC) Study cohort to illustrate how one can choose the optimal set of SNPs for a genetic risk sc ...[more]