Transcriptomics

Dataset Information

0

Platelet Reactivity ExpreSsion Score Predicts Cardiovascular Risk


ABSTRACT: Platelets are key mediators of atherothrombosis; yet, limited tools exist to identify individuals with a hyperreactive platelet phenotype. Here we derive and validate a Platelet Reactivity ExpreSsion Score (PRESS) integrating platelet aggregation responses and RNA sequencing in multiple cohorts. PRESS performs well in identifying a hyperreactive phenotype in patients with cardiovascular disease (AUC [cross-validation] 0.81, 95% CI 0.68 to 0.94), with similar discrimination in an independent cohort of healthy participants (AUC [validation] 0.77, 95% CI 0.75 to 0.79); accuracy 80%, sensitivity 71%, and specificity 86%. Next, we validate PRESS in multiple cohorts of patients with platelet RNASeq available. Following multivariable adjustment, PRESS was significantly higher in MI (β=1.8, p=0.02), and individuals with a score above the median more frequently develop a future cardiovascular event (adjusted HR 1.90, CI 1.07 to 3.36), p=0.027). Altogether, we provide strong evidence that PRESS is a robust prognostic marker, which could have an essential role in facilitating a personalized approach to cardiovascular risk management.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232027 | GEO | 2024/06/30

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-12-06 | E-GEOD-38511 | biostudies-arrayexpress
2013-12-06 | GSE38511 | GEO
2015-10-24 | E-GEOD-74224 | biostudies-arrayexpress
2018-02-18 | GSE95246 | GEO
2015-10-24 | GSE74224 | GEO
2020-02-10 | GSE92986 | GEO
2023-09-20 | GSE240273 | GEO
2012-05-03 | E-GEOD-37710 | biostudies-arrayexpress
2018-10-01 | GSE104251 | GEO
2021-11-09 | GSE179950 | GEO