Small lipidated anti-obesity compounds derived from neuromedin U.
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ABSTRACT:
SUBMITTER: Micewicz ED
PROVIDER: S-EPMC4543588 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Small lipidated anti-obesity compounds derived from neuromedin U.
Micewicz Ewa D ED Bahattab Omar S O OS Willars Gary B GB Waring Alan J AJ Navab Mohamad M Whitelegge Julian P JP McBride William H WH Ruchala Piotr P
European journal of medicinal chemistry 20150714
A small library of truncated/lipid-conjugated neuromedin U (NmU) analogs was synthesized and tested in vitro using an intracellular calcium signaling assay. The selected, most active analogs were then tested in vivo, and showed potent anorexigenic effects in a diet-induced obese (DIO) mouse model. The most promising compound, NM4-C16 was effective in a once-weekly-dose regimen. Collectively, our findings suggest that short, lipidated analogs of NmU are suitable leads for the development of novel ...[more]
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