Ontology highlight
ABSTRACT:
SUBMITTER: Hashimoto H
PROVIDER: S-EPMC4543634 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Hashimoto Hideharu H Zhang Xing X Vertino Paula M PM Cheng Xiaodong X
The Journal of biological chemistry 20150707 34
One of the most fundamental questions in the control of gene expression in mammals is how the patterns of epigenetic modifications of DNA are generated, recognized, and erased. This includes covalent cytosine methylation of DNA and its associated oxidation states. An array of AdoMet-dependent methyltransferases, Fe(II)- and α-ketoglutarate-dependent dioxygenases, base excision glycosylases, and sequence-specific transcription factors is responsible for changing, maintaining, and interpreting the ...[more]