Ontology highlight
ABSTRACT:
SUBMITTER: Horai R
PROVIDER: S-EPMC4544742 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Horai Reiko R Zárate-Bladés Carlos R CR Dillenburg-Pilla Patricia P Chen Jun J Kielczewski Jennifer L JL Silver Phyllis B PB Jittayasothorn Yingyos Y Chan Chi-Chao CC Yamane Hidehiro H Honda Kenya K Caspi Rachel R RR
Immunity 20150801 2
Activated retina-specific T cells that have acquired the ability to break through the blood-retinal barrier are thought to be causally involved in autoimmune uveitis, a major cause of human blindness. It is unclear where these autoreactive T cells first become activated, given that their cognate antigens are sequestered within the immune-privileged eye. We demonstrate in a novel mouse model of spontaneous uveitis that activation of retina-specific T cells is dependent on gut commensal microbiota ...[more]