Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.
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ABSTRACT:
SUBMITTER: Engel BJ
PROVIDER: S-EPMC4545642 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.
Engel Brian J BJ Constantinou Pamela E PE Sablatura Lindsey K LK Doty Nathaniel J NJ Carson Daniel D DD Farach-Carson Mary C MC Harrington Daniel A DA Zarembinski Thomas I TI
Advanced healthcare materials 20150609 11
Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture. ...[more]
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