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Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.

ABSTRACT: Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture.

SUBMITTER: Engel BJ 

PROVIDER: S-EPMC4545642 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.

Engel Brian J BJ   Constantinou Pamela E PE   Sablatura Lindsey K LK   Doty Nathaniel J NJ   Carson Daniel D DD   Farach-Carson Mary C MC   Harrington Daniel A DA   Zarembinski Thomas I TI  

Advanced healthcare materials 20150609 11

Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture. ...[more]

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