Ontology highlight
ABSTRACT:
SUBMITTER: Fong EL
PROVIDER: S-EPMC4096229 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Fong Eliza L S EL Martinez Mariane M Yang Jun J Mikos Antonios G AG Navone Nora M NM Harrington Daniel A DA Farach-Carson Mary C MC
Molecular pharmaceutics 20140429 7
The lack of effective therapies for bone metastatic prostate cancer (PCa) underscores the need for accurate models of the disease to enable the discovery of new therapeutic targets and to test drug sensitivities of individual tumors. To this end, the patient-derived xenograft (PDX) PCa model using immunocompromised mice was established to model the disease with greater fidelity than is possible with currently employed cell lines grown on tissue culture plastic. However, poorly adherent PDX tumor ...[more]